Molecular pathology of breast cancer
نویسندگان
چکیده
منابع مشابه
The molecular pathology of hereditary breast cancer.
Hereditary breast cancer arising in carriers of mutations in the BRCA1 and BRCA2 genes differs from sporadic breast cancer and from non-BRCA1/2 familial breast carcinomas. Most BRCA1 carcinomas have the basal-like phenotype and are high-grade, highly proliferating, estrogen receptor-negative and HER2-negative breast carcinomas, characterized by the expression of basal markers such as basal kera...
متن کاملbreast cancer: genetics, risk factors, molecular pathology and treatment
breast cancer within incident of one million new cases each year has become one of the most common malignancies and leading cause of death among females. this disease is comprised of about 18% of women cancers. the availability of early detection and improved treatments may decrease the mortality rates which reflected in the united states and many other western countries. breast cancer in over ...
متن کاملHereditary breast cancer: from molecular pathology to tailored therapies.
Hereditary breast cancer accounts for up to 5-10% of all breast carcinomas. Recent studies have demonstrated that mutations in two high-penetrance genes, namely BRCA1 and BRCA2, are responsible for about 16% of the familial risk of breast cancer. Even though subsequent studies have failed to find another high-penetrance breast cancer susceptibility gene, several genes that confer a moderate to ...
متن کاملMolecular Docking of Curcumin With Breast Cancer Cell Line Proteins
Background: Breast cancer is known as the most widely recognized dangerous tumors; therefore, the most common reason for mortality among all instances of harmful neoplastic illness in females. This is because the lack of specific signs and symptoms at the early stage and at the aggressive nature. Currently, breast cancer treatment such as chemotherapy, surgery and radiotherapy has not been effe...
متن کامل[Molecular pathology of colorectal cancer].
The identification of several types of familial colorectal cancer has led to the discovery of some of the genes involved in these diseases. It was subsequently shown that somatic mutations of these genes (APC, mismatch repair genes, TP53) also occur in sporadic colorectal cancer. Gradually, this molecular information is being incorporated into the standard histopathological analysis of colorect...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2002
ISSN: 1465-542X
DOI: 10.1186/bcr464